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Meso Scale Diagnostics LLC computational polymer model
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NuMED Inc scaled-down version of a human dbs lead (2f diameter, 8 annular electrode contacts: height, spacing)
Model geometry and FEM. (A) The geometry of the fiber pathways in the PPTg area in relation to the <t>DBS</t> <t>lead</t> location. CTG, central tegmental tract—orange; ON, oculomotor nerve—purple; SCP, superior cerebellar peduncle—red; MLF, medial longitudinal fasciculus—blue; ML, medial lemniscus—green; LL, lateral lemniscus—yellow; PPTg, pedunculopontine tegmental nucleus—gray. (B) Sagittal view of the geometry of the modeled fiber pathways. (C) The FEM geometry, showing the lead location and grounded chamber. (D) Electric potential isosurfaces for the anisotropic and isotropic model.
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Model geometry and FEM. (A) The geometry of the fiber pathways in the PPTg area in relation to the DBS lead location. CTG, central tegmental tract—orange; ON, oculomotor nerve—purple; SCP, superior cerebellar peduncle—red; MLF, medial longitudinal fasciculus—blue; ML, medial lemniscus—green; LL, lateral lemniscus—yellow; PPTg, pedunculopontine tegmental nucleus—gray. (B) Sagittal view of the geometry of the modeled fiber pathways. (C) The FEM geometry, showing the lead location and grounded chamber. (D) Electric potential isosurfaces for the anisotropic and isotropic model.

Journal: Frontiers in Computational Neuroscience

Article Title: Subject-specific computational modeling of DBS in the PPTg area

doi: 10.3389/fncom.2015.00093

Figure Lengend Snippet: Model geometry and FEM. (A) The geometry of the fiber pathways in the PPTg area in relation to the DBS lead location. CTG, central tegmental tract—orange; ON, oculomotor nerve—purple; SCP, superior cerebellar peduncle—red; MLF, medial longitudinal fasciculus—blue; ML, medial lemniscus—green; LL, lateral lemniscus—yellow; PPTg, pedunculopontine tegmental nucleus—gray. (B) Sagittal view of the geometry of the modeled fiber pathways. (C) The FEM geometry, showing the lead location and grounded chamber. (D) Electric potential isosurfaces for the anisotropic and isotropic model.

Article Snippet: The high-field imaging, along with results from electrophysiological microelectrode mapping of the PPTg area, were superimposed in Monkey Cicerone (Miocinovic et al., ) to define a trajectory for unilateral implantation of a scaled-down version of a human DBS lead (2F diameter, 8 annular electrode contacts: 0.5 mm height, 0.25 mm spacing) (NuMed, Hopkinton, NY) in the region of the PPTg (right hemisphere).

Techniques: